0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK & STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK & STOCKHOLDERS' EQUITY (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Asset Acquisitions link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value of Financial Assets and Liabilities link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Intangible Assets, net link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Common Stock link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Stock-based Compensation link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Series A Convertible Preferred Stock link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Significant Agreements link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Long-Term Obligations link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Related-Party Transactions link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Segment and Geographic Information link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Fair Value of Financial Assets and Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Intangible Assets, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Segment and Geographic Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Nature of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Summary of Significant Accounting Policies - Segment Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Summary of Significant Accounting Policies - Off-Balance Sheet Risk and Concentrations of Credit Risk (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Summary of Significant Accounting Policies - Product Revenue Allowance and Reserve Categories (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Summary of Significant Accounting Policies - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Prepaid expenses and other current assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Other Long-Term Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Net loss per share (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Patent Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Summary of Significant Accounting Policies - Application of New or Revised Accounting Standards (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Asset Acquisitions - LG Chem, Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Asset Acquisitions - Xinvento B.V. (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Fair Value of Financial Assets and Liabilities - Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Fair Value of Financial Assets and Liabilities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Fair Value of Financial Assets and Liabilities - Changes in Embedded Derivative Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Fair Value of Financial Assets and Liabilities - Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Intangible Assets, net - Schedule of finite-lived intangible assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Intangible Assets, net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Intangible Assets, net - Amortization expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Common Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-based Compensation - 2017 Equity Incentive Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stock-based Compensation - 2022 Inducement Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Stock-based Compensation - 2017 Employee Stock Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Stock-based Compensation - Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Stock-based Compensation - Black Scholes option pricing (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Stock-based Compensation - Common stock option activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Stock-based Compensation - RSU and PSU activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Stock-based Compensation - RSU and PSU Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Stock-based Compensation - Stock-based compensation expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Series A Convertible Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Significant Agreements -RareStone Group Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Significant Agreements - Ipsen Pharma S.A.S. (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Significant Agreements - Camurus (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Long-Term Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes - Components of income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income Taxes - Components of provision for income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Income Taxes - Reconciliation of income tax rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Income Taxes - Deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Segment and Geographic Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Segment and Geographic Information - Profit (loss) (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Segment and Geographic Information - Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink